Phentolamine with magnesium sulfate treatment of neonatal persistent pulmonary hypertension of 40 Cases.doc

 PAGE \* MERGEFORMAT 9 Phentolamine with magnesium sulfate treatment of neonatal persistent pulmonary hypertension of 40 Cases [Abstract] Objective To observe the decrease of magnesium sulfate with phentolamine treatment of persistent pulmonary hypertension of newborn. Methods 40 cases of neonatal persistent pulmonary hypertension, primary disease in the active treatment at the same time, give oxygen hood or simple continuous positive airway pressure ventilation, insulation, fluid replacement, anti-inflammatory, correcting acid, improve microcirculation, corrected calcium, sodium and other symptomatic and supportive treatment. Dopamine 3 ~ 5 μg / (kg · min to maintain systemic blood pressure, so that systolic blood pressure of not less than 8 kPa , pay attention to the environmental stability. On the other hand loading dose of magnesium sulfate to give 200 mg / kg, intravenous infusion of 10% concentration, 0.5 h within the pump to push finished, after 20 ~ 50 mg / (kg · d maintained. according to the disease interval of 8 h 1 can be repeated drug use, medication time, no more than 7 d. allowing blood magnesium concentration was maintained at 3.5 ~ 5.5 mg / (kg · h), under the condition improved after gradual reduction of magnesium sulfate level, until significant improvement in cyanosis, PaO2 rise to a stable level. with the given phentolamine 0.5 ~ 1 mg / (kg · h, and ECG, blood oxygen saturation monitoring, if the improvement in oxygen saturation in children, can be 10 μg / (kg · min speed to maintain until the oxygen saturation rose to normal and stable, gradually reducing. above all with the injection pump control input speed. observe the effect in children. Results After treatment of 31 cases of children bruising disappears in 5 ~ 15 d, 7 ~ 16 d blood in normal, cardiac murmur in 2 ~ 27 d disappear .6 cases of meconium aspiration pneumonia and respiratory failure discharged improved, 3 cases of severe infection, hypoxia, or pulmonary hemorrhage complic