Phosphocreatine on myocardial ischemia reperfusion injury of mitochondrial MDA SOD and expression of Ca2 +.docVIP

 PAGE \* MERGEFORMAT 12 Phosphocreatine on myocardial ischemia reperfusion injury of mitochondrial MDA SOD and expression of Ca2 + Of: Meng Xiangyan package of high long-Bin Luo Yuanyuan Xiao Group [Abstract] Objective To study creatine phosphate (PCr) on ischemia-reperfusion (I / R) injury in heart mitochondria. Methods The rat left anterior descending coronary artery ligation rat I / R model .60 male rats were randomly divided into ischemia-reperfusion (I / R) injury, sham operation group, PCr group, sham operation group only thoracotomy without coronary ligation, producing more than two sets of I / R model, PCr group 45 min before ligation femoral vein injection of PCr 4 mg / kg, sham operation group and I / R group were the corresponding volume of saline intravenously, 45 min of ischemia and 2 h, determination of I / R myocardium malondialdehyde (MDA), super- dismutase material (SOD) and total Ca2 + concentration. Results Compared with sham group I / R injury group, MDA, total calcium was significantly higher (P lt;0.05), SOD significantly decreased (P lt;0.01), and I / R injury group comparison, PCr group of MDA and total calcium content was significantly lower (P lt;0.05), SOD was significantly higher (P lt;0.01. Conclusion PCr on cardiac I / R injury in rats. [Keywords:] creatine phosphate, ischemia reperfusion injury, mitochondria Myocardial ischemia phosphocreatine (PCr) is a major function of the most direct material, and endogenous PCr extremely limited, so provision of exogenous PCr in cellular energy supply can solve the fundamental problem of myocardial protection - energy. PCr exogenous foreign scholars can restore depleted energy reserves added, made a lot of research, and can easily be proved that PCr is a form of energy used in myocardial cells (1.) marker was found through the myocardial PCr in the radioactive distribution, prove that exogenous PCr PCr can increase the overall level of the cell, and when myocardial ischemia, this