Phosphorylation of ERK1 - 2 in non-small cell lung cancer and its significance.docVIP

 PAGE \* MERGEFORMAT 12 Phosphorylation of ERK1 / 2 in non-small cell lung cancer and its significance 【Key Words】 phosphate Abstract: Objective: To investigate the phosphorylation of ERK1 / 2 in non-small cell lung cancer occurrence and development of the role and its relationship with the relationship between Ki67 expression. Methods: Using immunohistochemical staining to detect 10 cases of normal lung tissue and 64 cases of non-small cell lung cancer PERK, Ki67 expression. Results: The lung cancer tissues PERK and nuclear positive rate of the overall positive rate of 57.8%, 45.3%, normal lung tissue are all negative. PERK and TNM stage, lymph node metastasis (P lt;0.05); PERK and Ki67 expression in lung cancer was no correlation (Pgt; 0.05). Conclusions: ERK1 / 2 mediated signal transduction pathway may be in non-small cell lung cancer, the process of development play an important catalytic role. Keywords:: non-small cell lung cancer; extracellular signal-regulated kinase; phosphorylation Extracellular signal-regulated kinase (extracellular signalregulated kinases, ERKs) is the study of a clearer mitogen-activated protein kinase (mitogenactivated protein kinase, MAPK) pathway, the family includes at least two isoforms Erk1 and Erk2, mainly involved in cytokine and growth factor-induced signal transduction. In recent years, studies have shown that, ERK1 / 2 activation and over-the occurrence of cancer [1]. This study by detecting the phosphorylation of ERK1 / 2 and Ki67 in non-small cell lung cancer (nonsmall cell lung carcinoma, NSCLC) tissues, to investigate the activation of ERK1 / 2 in NSCLC in the role. 1 Materials and methods 11 Material Wuhan University Zhongnan Hospital, Wuhan, Hubei Province Cancer Hospital and a hospital from May 2001 to November 2003 filed by the pathology of non-small cell lung cancer diagnosed 64 cases of paraffin-embedded (30 cases with lymph node metastasis, 34 patients without lymph