Pill Dangguibuxuetang Modified cyclophosphamide chemotherapy on S180 sarcoma model of nude mice_0.doc

 PAGE \* MERGEFORMAT 12 Pill Dangguibuxuetang Modified cyclophosphamide chemotherapy on S180 sarcoma model of nude mice Study: Solutions Bin, Huang Xuejun, LIU Man-Hua, Zeng will, Huang Qiong, Du Tieliang [Abstract] Objective To observe Pill DGBXT Modified cyclophosphamide chemotherapy for synergies attenuated tumor. Methods nude mice inoculated with S180 sarcoma, cyclophosphamide and intraperitoneal injection, combined Pill Modified Dangguibuxuetang high, low dosage, was observed after 10 d the number of red blood cells in nude mice, hematocrit, tumor weight, tumor coefficient. The results of cyclophosphamide could significantly decrease the weight of nude mice sarcoma and sarcoma coefficient, a significant reduction in nude mouse spleen index, erythrocyte and hematocrit, Modified Pill Dangguibuxuetang coadministration with nude mice can further reduce the weight and sarcoma sarcoma coefficient, increased spleen index, significantly increased the number of red blood cells and hematocrit. pathologic examination showed enrichment Modified Dangguibuxuetang after pill combined with cyclophosphamide significantly enhanced tumor cell necrosis, decreased tumor cell density and reduce the number of tumor cells. Conclusion Pill DGBXT Modified chemotherapy of cyclophosphamide significantly attenuated tumor synergism. [Keywords:] Modified Dangguibuxuetang Pill; cyclophosphamide; S180 sarcoma Abstract: ObjectiveTo observe the reducing toxicity and increasing effect of modified Danguibuxuetang concentrated pills (MDCP) on S180 tumor model in BALB / c-nu / nu treated with CTX.MethodsS180 cell was implanted into BALB / c-nu / nu and CTX combined with ig MDCP. The number of red blood cell, hematocrit, tumor weight, tumor factor were observed after medicating 10d.ResultsMDCP combined with CTX could further reduce the tumor weight and tumor factor, increase the number of red blood cell and hematocrit in BALB / c -nu/nu tumor model. Pathological examination revealed