Pharmacological pain Ping Ointment Study.doc

 PAGE \* MERGEFORMAT 10 Pharmacological pain Ping Ointment Study Cao Yin, Zhou Jianping, Wang Zhibin 【Abstract】 Objective To investigate the pain levels paste the main pharmacological action and to provide experimental basis for clinical application. Methods hot-plate test, acetic acid-induced pain in a mouse model law to observe its analgesic effect; with carrageenan, xylene-induced rats and mice with acute inflammation model, investigate its anti-inflammatory effect; use of dextran-induced microcirculation mouse model to study the role of pain and blood circulation flat paste. Results cream can increase the pain level to stimulate the animal due to heat-induced pain on pain threshold, reduce the acetic acid writhing response stimuli occurred only a few animals; on carrageenan-induced toe swelling inhibition reduces 2 Toluene-induced mouse ear swelling of the swelling degree; pairs of intravenous injection of dextran solution in mice caused by microcirculatory disturbances, with a clear improvement. Conclusion pain Ping Ointment has analgesic, anti-inflammatory and pharmacological effects of promoting blood circulation. Keywords: pain Ping Gao; analgesic effect; anti-inflammatory effect; blood circulation effect 【Abstract】 Objective To study the principal pharmcodynamics of Tongping ointment and provide experimental data for clinical application. Methods Methods of acetic acid-induced writhing and hot-plate test in mice were used to study the analgesic effect. Models of acute inflammatory reactions of xylene -induced mouse ear edema and carrageen-pastern-induced rat paw edema were performed to study the anti-inflammatory effects. To prepare the model of mouse ears microcirculatory disturbance by intravenous injection of dextran solution for observing promoting blood circulation effect of Tongping ointment. Results The pain threshold was remarkably improved and the number of writhing mice induced by acetic acid were decreased. Tongping