- 1、本文档共11页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
Pioglitazone on LPS induced cortical neurons in vitro release of NO
PAGE \* MERGEFORMAT 11
Pioglitazone on LPS induced cortical neurons in vitro release of NO
[Abstract] Objective To study pioglitazone (pioglitazon, Pio) inhibited LPS (lipopolysaccharide, LPS) cultured cortical neurons caused by increased release of nitric oxide and its inhibition of signal transduction mechanisms. Methods and cultured for 6 to 7 d neonatal rat cortical neurons as the research object, the establishment of lipopolysaccharide injury and pioglitazone protection model. Griess method using cell culture supernatant NO content. Results LPS can lead to nerve cell damage, NO content was increased in culture medium , pioglitazone (1 mol / L significantly inhibited the LPS induced increase of NO content. Conclusions Pioglitazone significantly antagonized LPS-induced nerve cell damage.
[Keywords:] pioglitazone, lipopolysaccharide, neurons, NO
Abstract: Objective To explore the express effects of pioglitazon (Pio) on lipopolysaccharide-induced NO production to cultured cortical neurons and investigate its signaling pathway. Methods The inflammatory neurotoxicity model was constructed in primary cortical neurons isolated from Sprague-Dawley rats 6 ~ 7 d neonate rats following a dose lipopolysaccharide to the neurons directly. The contents of NO was detected. Results The cells, exposed to LPS (10 g / mL for 8 h), showed charateristic change of damage, which could be relieved by pioglitazon (1 mol / L) with cell survival rate increment. Pioglitazone could block the increase of NO induced by LPS. Conclusions Pioglitazone can prevent the neurons from the damage of LPS inflammatory neurotoxicity.
Keywords:: pioglitazon; lipopolysaccharide; neurons; NO
Recent studies have shown that brain inflammation involved in Alzheimer’s disease (Alzheimer’s disease, AD) and Parkinson’s disease (Parkinson isease, PD) and other neurons in the pathogenesis of degenerative diseases [1]. Lipopolysaccharide (lipopolysaccharide, LPS is a kind of amino-glycoside as a
您可能关注的文档
- Phenolic resin laminate substrate to characterize the products of vacuum pyrolysis_0.doc
- Phenol - sulfuric acid method Scorzonera roots of peach leaf polysaccharide.doc
- Phentolamine La Mingzuo infantile bronchopneumonia Observation of 40 Cases.doc
- Phentolamine dopamine furosemide treatment of refractory heart failure with pulmonary heart disease experience of 32 cases.doc
- Pheochromocytoma complicated with acute myocardial infarction caused by cardiac arrest in 1 case.doc
- Phenytoin on the carotid artery of atherosclerotic plaque.doc
- Pheochromocytoma perioperative nursing.doc
- Phentolamine treatment with low molecular weight heparin efficacy of pulmonary heart disease.doc
- Pheretima parameters on soil water content and pH value of Factor Selection.doc
- Phenytoin and insulin for comparative efficacy of bedsore dressing.doc
- 2024年中国钽材市场调查研究报告.docx
- 2024年中国不锈钢清洗车市场调查研究报告.docx
- 2024年中国分类垃圾箱市场调查研究报告.docx
- 2024年中国水气电磁阀市场调查研究报告.docx
- 2024年中国绿藻片市场调查研究报告.docx
- 2010-2023历年初中毕业升学考试(青海西宁卷)数学(带解析).docx
- 2010-2023历年福建厦门高一下学期质量检测地理卷.docx
- 2010-2023历年初中数学单元提优测试卷公式法(带解析).docx
- 2010-2023历年初中毕业升学考试(山东德州卷)化学(带解析).docx
- 2010-2023历年初中毕业升学考试(四川省泸州卷)化学(带解析).docx
最近下载
- 2019电工电子类教学实践耗材需求明细表.DOC
- My Life in China and America [容闳自传:我在中国和美国的生活].pdf
- 常熟银行研究报告:回归小微初心,乘风乡村振兴.doc VIP
- 浙商证券-宠物行业从乖宝宠物看宠物赛道:陪伴需求催化宠物新蓝海,食品赛道频现龙头.pdf
- ctgd-sop v5风口安装作业指导书.pdf VIP
- 消化道出血有关试题附有答案.docx VIP
- 湘教版美术《家乡的古建筑》说课稿.doc
- 上海地区不同垂直骨面型成人临床冠中心高度的比较研究.pdf VIP
- 2023年 AMC 10B 数学竞赛(原卷+答案).doc VIP
- 世界贸易组织.ppt VIP
文档评论(0)