Phenytoin on the carotid artery of atherosclerotic plaque.doc

 PAGE \* MERGEFORMAT 10 Phenytoin on the carotid artery of atherosclerotic plaque Of: Zhaolian Dong, Zhao Ying, Zhang Xinyong, Guohui Qin, Liu Bofu, Wang Zengjun, Fan Yunqing [Abstract] Objective To study the phenytoin on carotid atherosclerotic plaques. Methods hospitalized due to cerebral infarction by color Doppler ultrasound and found to have carotid artery atherosclerotic plaques in 66 cases the patients were divided into two groups, the control group and the phenytoin group, all 33 cases, two patients were routine anti-platelet aggregation, and decreased fibrin treatment, phenytoin phenytoin treatment group to 0.2g / d oral treatment for 90 days before and after treatment of the carotid artery plaque 1, before and after treatment of carotid atherosclerotic plaque area and plaque area the size of the maximum thickness of the carotid intima. The results comparing before and after treatment, after treatment, phenytoin group significantly reduced carotid plaque area (P lt;0.05, control group before and after treatment did not change significantly (Pgt; 0.05, carotid artery intima-media thickness in both groups before and after treatment no significant change (Pgt; 0.05, but the phenytoin group after treatment than before patches become mostly smooth surface. Compared with the control group, after treatment of carotid artery plaque area phenytoin group was significantly lower than the control group (P lt;0.05. Conclusion phenytoin therapy can reduce carotid artery plaque, and plaque fibrous cap has a stabilizing effect . [Keywords:] phenytoin, atherosclerosis [Abstract] Objective To investigate the effect of Phenytoin for carotid atherosclerotic plaques.Methods 66 acute cerebral infarction patients with carotid atherosclerotic plaques detected by colour-doppler sonography were enrolled and randomly divided into placebo group and Phenytoin group. Both groups were treated with anti- platelet and reduce-fibrin, while Phenytoin group was infused with 1