Pioglitazone on rat visceral fat and insulin resistance in obesity.doc

 PAGE \* MERGEFORMAT 7 Pioglitazone on rat visceral fat and insulin resistance in obesity Author: Hao Xiaolin, Zhaoming Jin, Zhang Zhili, Li Tianping [Abstract] Objective: To investigate the environmental factors of visceral obesity and insulin resistance, pioglitazone and observe its effects. Methods: 59% 4 weeks in rats fed high-fat diet made #8203;#8203;of animal model of insulin resistance, given pioglitazone intervention for 4 weeks, observe the visceral fat on insulin sensitivity and pioglitazone for its intervention. Results: 59% high-fat diet fed after 8 weeks, the model control group than in the normal control group, fasting blood glucose and insulin were significantly increased, blood lipids, serum free fatty acids (FFA) also significantly increased. given pioglitazone intervention drug intervention group than in the control group fasting blood glucose and insulin were significantly reduced blood lipids, serum FFA also significantly reduced. Conclusion: High-fat diet may induced visceral obesity and lead to insulin resistance, and pioglitazone may interfere with this process. [Keywords] rats, insulin resistance, free fatty acids, pioglitazone Insulin resistance is a variety of diseases, especially diabetes and cardiovascular disease risk factors in common, breeding a variety of metabolic-related diseases is a common soil and it’s genetic and environmental occurrence is closely related with this issue focuses on environmental factors from the starting of insulin resistance pathogenesis and to observe their pioglitazone intervention. 1 Materials and Methods 1.1 Preparation of insulin resistance in rats Modeling method see [1]. Clean-level 6-week-old male inbred SD rats, 7 d after feeding adaptation, according to body weight were randomly divided into two groups, control group 8, in the model 22 The animals caged alone, the daily ration to eat, about 310kJ / d. normal control rats fed with normal animal feed, in the model fed with la