Piroxicam suppositories Preparation and Stability.doc

Piroxicam suppositories Preparation and Stability Abstract: Piroxicam (Piroxicam) is a oxicam non-steroidal anti-inflammatory drugs. Nineties, after the tablets, capsules etc. were introduced into States Pharmacopoeia cut. However, see the end of suppositories containing relevant. Piroxicam anti-inflammatory activity than indomethacin, phenylbutazone, ibuprofen and aspirin, its long half-life, dosage is small, inexpensive, but the oral administration of the gastrointestinal tract with serious incentives. Come to my hospital treatment of orthopedic patients is very large, a doctor’s prescription non-steroidal anti-inflammatory drugs many opportunities, in order to meet the clinical use of drugs, reducing adverse drug reactions and economic burden of kin of patients, we have developed piroxicam suppositories. Its system of law is as follows: Weigh PEG 400 50g, added polyethylene glycol 600049.25g in a water bath heated to melt, add people passed sieve No. 6, piroxicam powder O.75g, stir until powder When all the dissolved to have to turn into suppository mold, condensation was removed after that. Using methods reported in the literature quality control. The strong light stability test results show that piroxicam suppository light instability, need to use plastic film packaging. Observation showed that samples left at room temperature, room temperature 3 months Piroxicam suppositories are still content to meet the requirements. In this study lay the foundation for further research. Piroxicam (piroxicam) is oxicam non-steroidal anti-inflammatory drugs. Nineties after having set out by national Pharmacopoeia. For example, the British Pharmacopoeia (1998 edition) reproduces piroxicam capsules and cold glue (piroxicamgel). United States Pharmacopoeia (24 Edition) reproduces capsules. Chinese Pharmacopoeia (1995 Edition) reproduces tablets, capsules and injections. Piroxicam anti-inflammatory activity than indomethacin, phenylbutazone, ibuprofen and aspirin. The pl