Platelet membrane glycoprotein Ⅵ (GP Ⅵ) Research Progress.doc

 PAGE \* MERGEFORMAT 33 Platelet membrane glycoprotein Ⅵ (GP Ⅵ) Research Progress Abstract Platelet membrane glycoprotein Ⅵ (GP Ⅵ) is an important platelet surface collagen receptor, can mediate the initial adhesion of platelets and collagen, resulting in signal transduction, increased integration of receptor affinity, causing platelet aggregation and thrombosis formation. Inhibit GP Ⅵ function significantly inhibited collagen-induced platelet adhesion, aggregation and thrombosis, and therefore development of new GP Ⅵ has become the main target of anti-platelet drugs. Over the past few years, the interaction of platelets and collagen research has made great progress in GP Ⅵ the structure of this paper, GP Ⅵ function, GP Ⅵ function-related factors, GP Ⅵ and clinical, etc. are reviewed. Keywords: platelet membrane glycoprotein Ⅵ; collagen; thrombosis Advances in the Studies of platelet glycoprotein Ⅵ (GP Ⅵ) - Review Abstractplatelet glycoprotein Ⅵ (GP Ⅵ) is a major receptor for collagen on the platelet surface. It mediates the initial platelet contact with collagen, generates intracellular signals, increases the affinity of integrin receptor, and causes platelet aggregation and thrombosis. Suppression of GP Ⅵ function can signicantly inhibit collagen-induced platelet adhesion, aggregation and thrombosis, so GP Ⅵ has become a novel target for antiplatelet therapy. Within the last few years, major advances have been made in understanding platelet-collagen interactions. In this paper, the advances of study on GP Ⅵ , including composition of GP Ⅵ, functions of GP Ⅵ, factors related with functions of GP Ⅵ, GP Ⅵ and clinic were summarized. Keywords:GP Ⅵ; collagen; thrombosis Platelet and vascular injury in the exposed parts of the extracellular matrix (extra cellular matrix, ECM) contact is the formation of thrombus, repair of damaged tissue and hemostasis of the first line of defense. Macromolecules in the ECM composition pla