Pills improvement of preparation method and device.doc

 PAGE \* MERGEFORMAT 10 Pills improvement of preparation method and device [Keywords:] Pill Abstract: Objective To introduce a new kind of pills preparation device for pills to study preparation process improvements, the establishment of a new process method. Methods of multiple pills dosage forms prepared using this device experiments. The results using the improved method of preparation of the Pill, roundness is good, smooth surface, uniform color, texture, moderate hardness, pills forming rate. Conclusion The drip system, device and method and conventional devices and methods of comparison, is simple, process a small, high efficiency and low cost, and the appearance of the product is good, pills weight difference is small, dose accuracy, product quality and easy to control, for industrial production and clinical application of all have a certain degree of promotion and application value. Keywords:: Pill; drip system speed; condensate; gradient cooling Pill means solid or liquid substances mixed with the substrate heating and melting, the trickle-down does not phase immiscibility of the condensate, since the molten droplets in the condensate in the role of interfacial tension contraction into a pill, followed by condensation into a solid form obtained. Pill agent is a form of solid dispersion, because it has a fast dissolution, bioavailability high, good curative effect and fewer side effects, drug stability and the preparation is simple, easy to control quality, etc. [1]. So be widely used in clinical treatment, pills because of its formulation advantages, in recent years, concern. However, as the technology and equipment is not quite complete, so preparation process difficult to control the re-emergence pill, round the whole degree of poor control of inadequate condensation temperature is not easy. Whether in research or teaching, research and experimental pills agent can not carry out better, so that Preparation of pills has been limited. To this end,