PLC delta1 gene in epithelial ovarian tumor and clinical significance.docVIP

 PAGE \* MERGEFORMAT 15 PLC delta1 gene in epithelial ovarian tumor and clinical significance OF: He Jianhui Yang Fen Tsai Mu-yen, Dan Xie [Abstract] [Objective] The purpose of this study PLC delta1 in epithelial ovarian tumors and its clinical significance. [Methods] Immunohistochemistry was used to detect PLC delta1 the 223 patients with epithelial ovarian cancer (183 cases of ovarian cancer and the control group, 40 cases of borderline ovarian tumors) tissue microarray expression; with clinical data, analysis of PLC delta1 expression in epithelial ovarian cancer. [results] in the effective detection of 197 cases of epithelial ovarian tumor samples Most (25 cases, 80.6%) borderline tumors showed normal expression, and in ovarian cancer, most (91 cases 54.8%) tumors occurred overexpression of PLC delta1, there were significant differences between the two (P lt;0.000 1); and PLC delta1 expression in ovarian cancer clinical stage, age of patients was significantly correlated (P lt;0.000 1). [Conclusion] PLC delta1 in ovarian cancer overexpression is closely related to malignant progression of tumors, Detection of ovarian cancer may be the future of a valuable new tumor marker. [Keywords:] ovarian tumor; PLC delta1; cancer gene Abstract: [Objective] To investigate the expression of PLC delta 1 in epithelial ovarian tumor and its clinical significance. [Method] Examination of PLC delta 1 expression in the tissue microarray among 223 cases of epithelial ovarian tumor (including 183 cases of ovarian cancer and the control group, 40 of borderline ovarian tumor), using immunohistochemistry method. Subsequent analysis was conducted to reveal the relationship between PLC delta 1 expression and the occurrence of epithelial ovarian cancer. [Results] Among 197 valid samples, most of the borderline tumor cases (25 samples, 80.6%) indicated normal expression of PLC delta 1; most of the ovarian cancer cases (91 samples, 54.8%), on the other hand, indicated overexp