Podocyte injury marks Desmin protein in rat model of hypothyroidism in the expression of renal and thyroid function in.doc

 PAGE \* MERGEFORMAT 17 Podocyte injury marks Desmin protein in rat model of hypothyroidism in the expression of renal and thyroid function in Of: Juan Wang Qian Zhang Songjun Wang Ruiying often Cham [ABSTRACT] Objective To observe hypothyroidism (hypothyroidism) renal injury podocyte injury marks Desmin protein expression in renal tissue to explore the mechanisms of renal injury hypothyroidism as well as the relationship between thyroid function. Methods Propyl thiouracil (PTU) rats fed with produce hypothyroidism. dynamic observation of the control group, respectively, hypothyroidism group and intervention group (given levothyroxine sodium (L-T4) to intervene and stop the treatment given PTU) rats renal pathological changes and injury, while immunohistochemical detection of Desmin in renal tissue. Results of the kidney injury in hypothyroid rats, and gradually increased with the progression and is closely related with thyroid function. intervention group renal tissue damage mitigation than hypothyroidism. Conclusion kidney of hypothyroidism associated with podocyte injury and thyroid hormone involved in podocyte injury. [Keywords:] hypothyroidism; kidney damage; Desmin; foot cell [Abstract] ObjectiveTo study the expression of the Desmin albumen in hypothyroidism rats, reveal the pathology of occurrence and development of the renal injury in hypothyroidism and explore the relationship in the renal injury and the thyroid function.MethodsModel of hypothyroidism rats was made by giving them propylthiouracil (PTU). The pathology condition of the control group and hypothyroidism group was examined by dynamic viewing. The immunohistochemistry was used todetermine the expression of Desmin albumen in the renal of the control, hypothyroidism and intervention groups (giving the levothyroxine sodium and stopping PTU ). ResultsThe renal injury appeared in hypothyroidism rats. With the development of the disease, the renal injury was aggravated progressively, w