Polycystic ovary syndrome ovulation induction after treatment of endometrial HOXA10 expression in.docVIP

 PAGE \* MERGEFORMAT 8 Polycystic ovary syndrome ovulation induction after treatment of endometrial HOXA10 expression in Author: Wang Wei, Xiao-Dong Li, HAO Gui-Min, Xu Su-yan [Abstract] Objective: To investigate the polycystic ovary syndrome (PCOS) after ovulation induction therapy in patients with endometrial homeobox A10 (HOXA10) levels of protein and gene expression characteristics. Methods: PCOS patients in 20 cases, the rules of the menstrual cycle 15 patients as the control group. PCOS patients with a small dose of hMG incremental approach to ovulation 2 ~ 3 cycles, select the success of ovulation induction treatment of patients with PCOS is not pregnancy, 12 patients in the control group 15 cases of menstrual cramps at 24 h within the endometrial curettage, OK HE staining of endometrial morphologic features and immunohistochemical determination of HOXA10 protein expression, and used RT  PCR used to detect endometrial HOXA10 mRNA expression. Results: The immunohistochemistry results showed that the PCOS group and control group could be seen specimens of endometrial HOXA10 protein expression, mainly expressed in glandular epithelial and stromal cells in the cytoplasm, while the PCOS group of endometrial HOXA10 protein expression was weaker than the control group. RT  PCR tests showed that PCOS Groups of endometrial HOXA10 mRNA expression level lower than the control group. Conclusion: PCOS after ovulation induction in patients with low expression of endometrial HOXA10 phenomenon may be related to impaired function of the endometrium. [Keywords:] Homeobox gene; polycystic ovary syndrome; endometrial 0 Introduction Homeobox A10 (HOXA10) [1] is an important transcription factors, cell development and control of embryonic development of the master genes. Endometrial adulthood experiencing active cyclical changes in the organization of such periodic destruction, and then build and restructuring process and the regulation of embryonic development t