Polygonatum mouse model of anti-hypoxic hypoxia in rats.docVIP

 PAGE \* MERGEFORMAT 5 Polygonatum mouse model of anti-hypoxic hypoxia in rats Author: Zhu Xin Yi, Wang Chang-song, XIE Jian-jun [Abstract] Objective: To study the Polygonatum hypoxic mice the anti-hypoxic effect, and to explore its mechanism. Methods: The atmospheric hypoxia experiments, sodium nitrite poisoning survival experiments, acute cerebral ischemia and hypoxia experiments, observe the mice were given Polygonatum concentrate fed for 4 weeks after the hypoxia tolerance, and heart, brain tissue MDA, GST, SOD determination. Results: Compared with control group, mice Polygonatum extended hypoxia, sodium nitrite poisoning, the survival time of the experiment to extend the experimental acute cerebral ischemia and hypoxia in mice breathing interrupted the first time, elevated serum SOD in levels and lower MDA content, the role of effect measure compliance with the existing relationship between the concentration of Polygonatum. Conclusion: Polygonatum hypoxic mice with anti-hypoxia effect, and enhancement of antioxidant ability of the mice. [Keywords:] odoratum; mouse; hypoxia model; anti-hypoxia effect; experimental study Polygonatum odoratum Polygonatum odoratum (MilI.) Druce (PO) Liliaceae Polygonatum, also known as luxuriant Rui, female wilt, sweet flat, slightly cold, with Ziyin Runzao, Yang Wei Sheng Jin’s power. Modern pharmacology study found that Polygonatum contains steroidal saponins, flavonoids, polysaccharides, alkaloids, cardiac glycosides and other components [1]. Polygonatum odoratum has enhancing immunity, lowering blood sugar, blood fat, anti-arteriosclerosis, anti-tumor and other effects [2-3]. This paper explores several hypoxia model, to give Polygonatum decoction concentrate fed for 4 weeks after the mice to hypoxia tolerance of change and to explore its mechanism. 1 Materials and methods 1.1 Drugs and reagents purchased from Polygonatum odoratum Pieces medicine company in Jiangsu Province, Henan origin. Identified by the hospital