Polygonum multiflorum Panax notoginseng extracts on non-alcoholic steatohepatitis in rat liver PPAR α PGC-1α levels in.doc

 PAGE \* MERGEFORMAT 3 Polygonum multiflorum Panax notoginseng extracts on non-alcoholic steatohepatitis in rat liver PPAR α PGC-1α levels in Author: Yu Yiqun LI Jun-xiang Ji Aidong [Abstract] Objective: To explore the fleece-flower root, 37 extract on rats with non-alcoholic steatohepatitis and liver tissue of PPAR α , PGC-1 α expression. Methods: 32 male SD rats were randomly divided into four groups of eight. In addition to the normal control group, a 10-week high fat fed rat model of non-alcoholic steatohepatitis. On modeling with immediate effect, the normal control group, model group were given daily 10 mL / kg of drinking water, traditional Chinese medicine group was given fleece-flower root, 37 extract, Yi Shan Yi Shan Fu group were re-fed. Delivery 10 weeks later, all rats were sacrificed, serum LDL, HDL, TG, ALT, AST, GGT; liver TG and PPARα , PGC-1α mRNA levels. Results: The Chinese Medicines Board of serum LDL levels decreased compared with model group (P amp;lt;0.05); medicine serum levels of HDL, TG, ALT, AST, GGT and liver TG levels decreased significantly compared with model group (P amp;lt;0.01), liver tissue PPAR α , PGC-1 α mRNA levels were significantly higher than the model group (P amp;lt;0.01). Conclusion: The fleece-flower root, 37 NASH extracts can reduce the serum and liver lipid synthesis and accumulation, reduce inflammation, so as to effectively control NASH, with a good clinical application prospect. [Keywords:] Shouwu; 37; extracts; non-alcoholic fatty liver disease; PPAR α , PGC-1 α 〔 Abstract〕 Objective To investigate the effect of the extracts of Heshouwu and Sanqi (Polygonum multiflorumThunb.and Panax no toginseng) on the expression of peroxisome proliferators-activated receptor α (PPAR α ) andPPAR gamma coactivator-1 (PGC-1α ) in non -alcoholic steatohepatitis (NASH) in rats. Methods The 32 maleSD rats were randomized into 4 groups with 8 in each. Rat model of non-alcoholic steatohepatitis was establishedwith fatty