Pomegranate polyphenols on Acute Liver Injury.doc

 PAGE \* MERGEFORMAT 8 Pomegranate polyphenols on Acute Liver Injury Of: Yang Lina YANG Ting-ting Lin Qian Fu Zhongxi [Abstract] Objective To observe the pomegranate polyphenols on the protective effect of liver injury in mice. Methods carbon tetrachloride (CCl4) induced acute liver injury model was pomegranate polyphenols (200,400,600 mg / kg) of small mouse serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity and liver superoxide dismutase (SOD) activity and malondialdehyde (MDA) content. The results of pomegranate polyphenols significantly reduced acute liver injury serum ALT, AST levels; and can reduce the liver, MDA, SOD activity increased. The body of the mice liver were lower than the ratio of liver injury model group. Conclusion Pomegranate polyphenols can protect against liver injury function, its effect may be related to the oxidation resistance. [Keywords:] pomegranate polyphenols; liver injury; carbon tetrachloride; lipid oxidation Pomegranate phytochemicals polyphenols Polyphenols are a class of hydroxy compounds, collectively, have antioxidant, anti-aging, anti-cancer anti-cancer, antibacterial, soothing beauty, lower blood pressure and preventing cardiovascular and cerebrovascular disease (1 to 3) and other Physiological and pharmacological activity, but at home and abroad of its less liver injury. In this study, prepared by CCl4 model of acute liver injury in mice, of pomegranate polyphenols on liver injury. 1 Materials and methods 1.1 40 male Kunming mice animals, body weight (20 + -2) g, Central South University Xiangya School of Medicine Division of Laboratory Animal Supply. Randomly divided into normal group, model group and low, medium and high doses of pomegranate polyphenols group 8 in each group. 1.2 reagents, instruments and medicines CCl4 (AR) was purchased from Beijing Chemical Reagent Company; alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase (SOD),