Power for heroin dependence rat neuronal apoptosis.docVIP

 PAGE \* MERGEFORMAT 19 Power for heroin dependence rat neuronal apoptosis [Abstract] Objective: To observe the hippocampus of heroin dependent apoptosis and the intervention of acupuncture, acupuncture treatment is to provide a theoretical basis. Methods: SD rats were randomly divided into 24 control and experimental groups, the experimental group increasing day by day according to the principle of dose 2 times a day, continuous subcutaneous injection of heroin, 9 days, 10 days with naloxone precipitated withdrawal, the establishment of heroin dependency model, and then the step down test test screening, and non-EA group divided into EA group, n = 8 animals, non-EA group to continue to give the maintenance dose of heroin, the EA group to stop administration, in a natural state of withdrawal, and select “Baihui”, “Ojo” in electrical acupuncture treatment, day 1 for 7 days, using TUNEL method, Envision immunohistochemistry rat hippocampus detected 3 cell apoptosis and apoptosis-related protein Bcl-2, Bax. Results: Compared with control group, a large non-electric acupuncture group apoptosis in the hippocampus was significantly higher (P lt;0.01), Bcl-2 protein expression decreased (P lt;0.01), Bax protein expression (P lt;0.01), compared with non-EA group, EA group hippocampal cell apoptosis index was significantly lower (P lt;0.01), Bcl-2 protein expression (P lt;0.01), Bax protein expression decreased (P lt;0.01). Conclusion: EA to promote the expression of Bcl-2 and inhibit the expression of Bax may be accelerate cell repair and protect brain tissue, to improve learning and memory ability of heroin dependent rats. [Keywords:] of heroin dependence, apoptosis, hippocampus, EA The Effect of Electroacupuncture on Apoptosis of Hippocampal Neurocyte in Heroin-addict Rats PAN Li, PAN Guishu (Department of Cardiology, Baotou Hospital of Tranditional Mongolian and Chinese Medicine, Baotou 014040, China; Department of Physiology, Zunyi Medical College)