Praeruptorin C Progress in cardiovascular pharmacology.doc

 PAGE \* MERGEFORMAT 9 Praeruptorin C Progress in cardiovascular pharmacology [Keywords:] praeruptorin C Cardiovascular pharmacological effects Pd for the Umbelliferae Peucedanum is a perennial herb, as the traditional Chinese medicine, has declared scattered wind-heat, cough and phlegm in effect, commonly used in cold, headache, cough, wheezing, chest tightness treatment. Studies show that praeruptorin C Pd is the main active ingredient, in addition to the role of these systems, the still strong performance of the cardiovascular pharmacology, cardiovascular effects of their research paper reviewed. An anti-ischemic, anti-heart failure Prevention grant Pra-C (praeruptorin C may improve LVH (left ventricular hypertrophy in cardiac function in rats, long-term application of LVH can significantly improve cardiac diastolic compliance [1], and through clinical observation, Pra-C increase in cardiac hypertrophy patients with cardiac diastolic amplitude time index, increased the relative amplitude of the RF wave, lower and diastolic A wave ratio of the total amplitude, indicating that Pra-C on myocardial hypertrophy in the improvement of compliance with a certain role [2]. Pra-C for short blood reperfusion heart CBF (coronary blood flow, CO (cardiac output, SV (cardiac volume and the recovery of HR, and Pra-C on normal perfusion of the heart CBF, CO, SV and HR was not obvious, and significantly lower Myocardial ischemia-reperfusion in the release of CK and mitochondrial Ca2 + content in decreased rates were 30% and 41% [3,4]. These show that the Pra-C with anti-ischemia activity. Pra-C self-regulation of guinea pig atrial inhibited, non-competitive antagonism CaCl2 and isoproterenol on myocardial frequency of the positive role of myocardial functional refractory period shortening [2] 235-238, in a concentration dependent negative inotropic effect [5]. Pra-C in the prevention and reversal of left ventricular hypertrophy at the same time, inhibition of KC