Population pharmacokinetics in the treatment of childrens medicines.doc

 PAGE \* MERGEFORMAT 14 Population pharmacokinetics in the treatment of children’s medicines [Keywords:] Population pharmacokinetics of drug therapy for children Traditional pharmacokinetic study sampling frequency, patients suffering large, it is difficult to promote in the clinical. Population pharmacokinetics of research methods to change the traditional research methods to obtain the pharmacokinetic parameters of the channel, by groups of research methods and Bayes method combined with feedback, you can more accurately estimate the individual pharmacokinetic parameters, optimize the regimen. In recent years, the rapid development of population pharmacokinetics, pharmacokinetics of domestic and foreign research groups, is increasing. Children are a special group, the child population pharmacokinetics studies are ongoing. But our group of children is still very limited pharmacokinetic studies in order to better improve the treatment of pediatric clinical drug level, push forward the process of children’s personalized medicine is on the population pharmacokinetics of knowledge and its implementation and applications briefly. A testing and evaluation of medicines for children facing difficulties Currently used treatments for childhood diseases, most adult patients prior to listing, based on the object for the study. As we all know, children are not miniature adults, children of drug treatment is different from adults. However, the particularity of groups of children, a number of drugs for clinical trials in adult ways, can not be applied to children. The current dosage for children come from the adult dose extrapolation, in terms of drug safety information is still not by a simple extrapolation to obtain, so people are eager to obtain directly from the groups of children of drug research information. At present, few clinical trials of medicines for children there are also many problems, such as the number of cases of inadequate or lack of testing is based,