Porcine brain extract on rat learning and memory in Alzheimers disease protection_0.doc

 PAGE \* MERGEFORMAT 13 Porcine brain extract on rat learning and memory in Alzheimer’s disease protection Of: Li Yongjin, Zhang Heyun, cloud cover, Chen Su Sin, Zhang Taiping, Luren Yun, Chen Yuefang, Huang Xiaojia [Abstract] Objective To observe the porcine brain extract on rat learning and memory in dementia and to explore its mechanism. Hippocampal CA1 microinjection method of quinolinic acid caused by Alzheimer disease (AD) rats. The rats were randomly divided into sham group the control group, porcine brain extract group, porcine brain extract on treatment group and positive drug cerebrolysin group. intramuscular administration, continuous administration of 30 d. using Y-maze and passive avoidance in rats jumping method the level of learning and memory; Determination MDA content in cerebral cortex and hippocampus of the NO content and NOS activity. Results Compared with control rats given extracts of porcine brain section 10,20,30 days, large rat maze, jump significantly fewer errors; administration of 30 d, rat cerebral cortex MDA, NO content and NOS activity in hippocampus was significantly decreased. Conclusion porcine brain extracts can improve learning and memory in rats dementia, and its mechanism of action related to the decrease rat brain MDA, NO, NOS related. [Keywords:] porcine brain extract; Alzheimer’s disease; learning and memory Alzheimer’s disease (Alzheimer’s Disease, AD) is a high correlation with age, for learning and memory, cognitive dysfunction as the main clinical symptoms, senile plaques, neurofibrillary tangles, neuronal loss as the main pathological changes in the central nervous system degenerative disease, its pathogenesis is not clear [1]. In developed countries, AD has become the heart disease, cancer, stroke after the first four human disease cause of death, so active on the research of AD significance. Animal brain extracts containing small peptides, nerve growth factor and other active ingredients for the tre