Praseodymium trichloride on serum tumor effects of interleukin -2.doc

 PAGE \* MERGEFORMAT 4 Praseodymium trichloride on serum tumor effects of interleukin -2 [Abstract] Objective: To study the different doses of three praseodymium on the tumor-bearing mice serum interleukin -2 effects. Methods: After modeling, in mice fed different doses of three praseodymium (20.0,10.0,2.0,0.1 mg.kg), 1 month later by enzyme-linked immunosorbent assay (ELISA) technique to detect serum IL - -2 level changes. Results: 0.1,2.0 mg.kg three praseodymium group would enable the level of serum interleukin -2 significantly increased tumor weight decreased; 10.0,20.0 three praseodymium group would enable the level of serum interleukin -2 significantly lower , tumor weight slightly increased, but no statistical significance. Conclusion: Low-dose three praseodymium can enhance immune function in tumor-bearing mice; while high-dose three praseodymium can reduce the immune function in tumor-bearing mice. [Keywords:] praseodymium trichloride; serum; S 180 tumor line; interleukin -2 Has now confirmed that plant foods contain a certain concentration of rare earth elements, with the extensive application of rare-earth elements, rare earth elements can enter the body through the digestive tract [1 ~ 2]. In this study, different doses of praseodymium trichloride by gavage administration of 1 month after a row to detect the tumor-bearing mice serum interleukin -2 change in order to explore rare earth elements on immune function. 1 Materials and methods 1.1 The material weight (20 ± 2) g healthy male Kunming strain mice 50, purchased at the Campus of Jilin University Experimental Animal Department, Xinmin; experiment trichloride Praseodymium Rare Earth by the National Agricultural Research Center, diluted with saline; S180 tumor strains from the Beijing Cancer Institute, ELISA kit purchased from Beijing Reagent Company tripod States, 1640 purchased from Hy-clone, DG3022-type enzyme-linked immunosorbent assay instrument (East China Electronic Instrument Facto