Preparation of saturated solution of puerarin CD inclusion of β.docVIP

 PAGE \* MERGEFORMAT 11 Preparation of saturated solution of puerarin CD inclusion of β OF: You Si Road, High Xiurong, Liao Changjun [Abstract] Objective To study prepared by saturated solution of puerarin optimum β cyclodextrin. Methods Preparation of saturated solution of puerarin β cyclodextrin and ultraviolet spectrophotometry puerarin content, UV, IR Spectra inclusion. The results obtained through the orthogonal optimal preparation of puerarin and β for the feed ratio of 1:1 cyclodextrin, inclusion time was 3h, inclusion temperature is 60 ℃, inclusion rate of up to 94%. Conclusions prepared saturated solution of puerarin β cyclodextrin inclusion process is simple and feasible, for the improvement of oral preparations of puerarin. [Keywords:] puerarin, β cyclodextrin, orthogonal ABSTRACT Objective To discuss the optimum technology of saturated water solution in preparing β-cyclodextrin inclusion compound of puerarin. Methods Ultraviolet spectrophotometry was applied to detect the content of puerarin, and ultraviolet spectrum and infrared spectrum were applied to verify the inclusion complex. Results Orthogonal test worked out the optimum preparation process: the feed ratio (mol ratio) of puerarin and β-cyclodextrin was 1:1, the inclusion time was 3 hours and the inclusion temperature was 60, then the inclusion rate reached 94%. Conclusions Satureated solution is of simple application in the preparation of β-cyclodextrin inclusion compound of puerarin, and it is suitable for the improvement of puerarin oral preparation KEYWORDS puerarin β-cyclodextrin inclusion compound orthogonal test Puerarin (puerarin, PU kudzu from legumes, kudzu root extract Gan a glycoside in the water solubility of 0.011 mol / L. with the expansion of coronary blood vessels, lower blood pressure and myocardial oxygen consumption, anti-arrhythmic and significantly limit the scope of myocardial infarction and other pharmacological effects, clinical hypertension, angina