Preparation of sustained-release tablets of artificial musk Technology.docVIP

 PAGE \* MERGEFORMAT 16 Preparation of sustained-release tablets of artificial musk Technology 【Abstract】 Objective To investigate the artificial musk sustained-release tablets of the preparation process. Methods of artificial musk, as a model drug, ethyl cellulose as the main framework sustained-release materials, using traditional solvent and improve the solvent after the preparation of solid dispersion tablet were measured in vitro dissolution. The results of X-ray experiments show that the existence of amorphous drugs in vitro dissolution results showed that the modified solvent method is superior to the traditional solvent method. Conclusion The modified solvent Preparation of artificial musk sustained-release tablets. Keywords: artificial musk sustained-release tablets release rate AbstractObjectiveTo prepare sustained-release tablets of muschus. MethodsThe EC sustained-release tablets of muschus were made by an improved solvent method and a traditional solvent method. The dissolution was observed. ResultsThe X-ray powder diffraction analysis conformed that muschus exited as an amorphous state . Their degrees of dissolution in vitro confirmed that the improved solvent method was better than the traditional solvent method. ConclusionSustained-release tablets of muschus can be made by an improved solvent. Keywords:Muschus; Sustained-Release Tablets; Dissolution Artificial musk at the end of 1993, the Ministry of Health has been approved as a class of raw material drug production, with similar features and natural musk indications and use of clinical practice is mainly used for the treatment of angina pectoris [1]. The main ingredient drug efficacy musk ketone is insoluble in water and other aqueous media, tablets made of because of its insoluble nature of the low bioavailability and rapid metabolism in vivo. Solid dispersion is to improve the in vitro dissolution of insoluble drugs is one effective way to improve the