Prevention and treatment of metformin on insulin resistance in the role of.doc

 PAGE \* MERGEFORMAT 4 Prevention and treatment of metformin on insulin resistance in the role of Diabetes mellitus (DM) is a group by a number of genetic and environmental factors caused by the combined effects of chronic, life-long non-communicable diseases. China is currently in the rise period DM, if not effectively contained, it is estimated in 2015 in China may have 60 million DM patients [1]. At present the view that insulin resistance (IR) and β-cell dysfunction in type 2 diabetes mellitus (T2DM) in the main pathogenesis [2]. IR associated with high insulin (INS) hyperlipidemia, glucose in the normal range during the best time to diabetes prevention and control, early behavioral intervention and drug intervention not only reduced the incidence of T2DM, but also to slow or correct the IR due to metabolic syndrome, prevention and treatment of DM during this period of great significance. T2DM, lipid metabolism disorders, hypertension, atherosclerosis (AS), coronary heart disease, visceral obesity has been known as the “metabolic syndrome”, which is one of the common causes of IR. Now that, in the early course of diabetes, no high blood sugar, most of the patients with IR already exists, and hyperlipidemia associated with high-INS to further develop, leading to pancreatic β-cell compensatory mechanism for a gradual decline, blood glucose increased, eventually occur T2DM. IR with high-INS hyperinsulinemia, predicting a single place an effective predictor of T2DM [3]. Metformin (MT) through weight loss, strengthening the role of the INS, inhibit glycogen production and reduce blood fat and reduce the IR. A weight loss Studies have shown that [4], MT in the treatment of polycystic ovary disease, even without dieting or not to increase the activity levels of the circumstances, it maid patients received weight loss. Confirmed by further studies, in 22 cases suffering from obesity, but no DM women and men with MT medication for 24 weeks,