Progress in chemotherapy antiemetic drugs.doc

 PAGE \* MERGEFORMAT 16 Progress in chemotherapy antiemetic drugs [Abstract] chemotherapy induced nausea and vomiting not only give rise to chemotherapy in patients with fear of affecting the course of treatment, but also due to loss of body fluids, etc., and severely weakened the body’s own resistance, is not conducive to the prognosis, so an effective antiemetic for chemotherapy is a must for small. Since the application of dopamine receptor antagonists, the chemotherapy antiemetic drugs has undergone continuous change to improve the current widely used 5_HT3 receptor antagonist ondansetron Qiongmai from the original to a second-generation drug (Pa Luonuo Division Joan, etc.) R amp;amp; D and applications, Aprepitant is marked to market a new generation of chemotherapeutic drugs NK_1 receptor antagonist antiemetic officially entered clinical use. In this paper, chemotherapy-induced nausea and vomiting associated with the mechanism and antiemetic drug research are reviewed. [Keywords:] antiemetic chemotherapy vomiting Chemotherapy drugs in killing tumor cells at the same time, but also as a toxic substance in the body damage to normal cells, the performance of their various side effects, especially the most common gastrointestinal reactions, 75% of chemotherapy patients will be varying degrees of nausea and and vomiting [1]. Severe vomiting will be induced by water-electrolyte imbalance, nutritional deficiencies, seriously weakened the body’s own resistance, adverse effects of treatment. Therefore, the in-depth study of the mechanism of chemotherapy-induced vomiting to timely and effective manner to prevent, not only can improve the patient’s quality of life, so that chemotherapy can also be carried out smoothly. In this paper, chemotherapy-induced nausea and vomiting mechanism and antiemetic drug research are reviewed. 1 Overview 1  1 chemotherapy induced nausea and vomiting classification Occur at different time points according to acute, delayed and