Progress in genetics of drug-resistant malaria parasites.docVIP

 PAGE \* MERGEFORMAT 18 Progress in genetics of drug-resistant malaria parasites Keywords:: Plasmodium genus; anti-malarial drugs; resistance; gene Abstract malaria parasite is resistant to malaria, one of the main problems encountered. Class of anti-folate anti-malarial drug resistance mechanisms are basically find out, rather than the role of the target enzyme dihydrofolate reductase, or dihydro-Butterfly acid synthase gene point mutations. Quinoline drug resistance impact factor is not yet fully understood. On chromosome 5 of Plasmodium falciparum multidrug resistance gene on chromosome 1 and 7 of the cg2 resistance-related genes may be genes, but both can not fully explain the resistance, yet in-depth study. The prevalence of malaria is still very wide, covering more than 90 countries and regions worldwide, 20 million people facing the risk of malaria. According to statistics, every year 300 million to 5 million cases of malaria, resulting in 1.5 million to 270 million deaths, of which 100 million are living in Africa, children under 5 years of age [1]. Long-term practice of mankind in the process of screening a large number of malaria drugs, but since the late 50s was found in Southeast Asia and South America respectively, Plasmodium falciparum chloroquine resistance after the Plasmodium falciparum chloroquine resistance spread rapidly spreading resistance to the increasing degree of , and from a single drug resistance to the development of multi-drug resistance. China’s Hainan, Yunnan and Guangxi provinces, autonomous regions and also have drug-resistant malaria epidemic. At present, the parasite on almost every anti-malarial drugs has produced a resistance to malaria control situation was very serious, urgently requires us to find out as soon as possible resulting drug resistance mechanisms in order to take measures to prevent or reverse the incidence of drug resistance and to guide drug discovery . In recent years, the development of molecular biolog