Progress in invasion and metastasis of breast cancer.doc

 PAGE \* MERGEFORMAT 23 Progress in invasion and metastasis of breast cancer [Abstract] Objective: Breast cancer is one of common malignant tumors in women in Western countries, the morbidity and mortality of malignant tumors of the first rank. In recent years the incidence of breast cancer in our country are on the rise, and the age of onset ahead of the trend. breast cancer invasion and metastasis is the key to cause deaths and prevent breast cancer invasion and metastasis of breast cancer in the modern key. Therefore, further study the molecular basis of metastasis of breast cancer cells, has become the increase the hot issues in breast cancer treatment. In this paper, invasion and metastasis of breast cancer to make an introduction. [Keywords:] breast cancer, invasion and metastasis, research progress Local infiltration of malignant tumors and distant metastasis is the leading cause of death of patients, to prevent breast cancer invasion and metastasis of breast cancer treatment is a modern key. Breast cancer invasion and metastasis of cancer cells and extracellular matrix interactions result, cancer cells from the primary tumor and attach to sites of metastasis of breast cancer invasion and metastasis is a key step. breast cancer invasion and metastasis is a common variety of genes involved in the complex process. In this process, one is cell adhesion molecules, cytoplasmic proteinases, cytokines and growth factors directly affect the activity state of invasion and metastasis of tumor cells, many normal cells in gene over-expression of type IV collagen production, such as protease, identify some of the integration of extracellular matrix proteins, transfer factors and their receptors, a variety of growth factors and their receptors such as bFGF and other proteins, thereby enhancing cell adhesion, invasion, campaigns, and reproductive capacity, the other aspects of some tumor suppressor genes and inhibit other genes that inhibit the loss and ina