Progress in solid lipid nanoparticles.docVIP

 PAGE \* MERGEFORMAT 15 Progress in solid lipid nanoparticles [Keywords:] solid lipid nanoparticles [Keywords:] solid lipid nanoparticles; synthesis; preparation; route of administration 0 Introduction Solid lipid nanoparticles (solid lipid nanoparticles, SLN) is the particle diameter of 10 ~ 1000 nm solid-state between the colloidal particles, which in solid natural or synthetic lipids such as lecithin, triglycerides, etc. as the carrier, the drug parcel or have embedded in the lipid nucleus is made of solid colloidal drug delivery systems, is the early 20th century, 90 developed an alternative to emulsions, liposomes and polymer nanoparticles in a new colloidal drug delivery systems [1] . It offers an outstanding advantage is a good physiological compatibility and can be biodegradable, controlled drug release and have a good target, while avoiding the organic solvents can not be completely removed shortcomings [2,3]. we review its preparation method and route of administration to discuss current problems and the application prospect. Preparation of 1SLN 1.1 Film Ultrasonic dispersion method will be suitable for lipid and drugs dissolved in organic solvents, vacuum rotary evaporator to remove the organic solvent to form a layer of lipid membrane, by adding an aqueous solution containing the emulsifier, the use of ultrasound instrument with a probe for ultrasonic dispersion can be small and uniform SLN. Hodoshima, etc. [4] to the synthesis of polyethylene glycol lipid (PEGlipid) and lecithin (PC) or dipalmitoyl phosphatidyl choline (DPPC) as the emulsifier, preparation 4O tetrahydropyran adriamycin (THPADM) prodrugs of the SLN, first THPADM esterification, and then with PEGlipid, PC, or DPPC, triolein, or 3:5:5:7 ratio of soybean oil to dissolve in methylene chloride methanol (4:1) mixed solvent, vacuum rotary evaporator to make into a thin layer of lipid membrane, and then adding 0.24 mol / L of glycerol solution, ultrasonic dispersion, was 30 ~ 50 nm g