Proteasome inhibitor bortezomib in combination with daunorubicin on HL 60 cells apoptosis and the expression of Survivin mRNA.docVIP

 PAGE \* MERGEFORMAT 11 Proteasome inhibitor bortezomib in combination with daunorubicin on HL 60 cells apoptosis and the expression of Survivin mRNA [Abstract] Objective: To study the proteasome inhibitor bortezomib (Bor) alone or in combination with daunorubicin (DNR) on HL 60 cells and Survivin mRNA expression. Methods: Different concentrations of Bor, DNR and the two drug combination group and control group acts on HL 60 cells, using MTT cell proliferation, RT PCR detection of Survivin mRNA expression results: 5 nmol / L Bor for 24 h for the HL 60 cell proliferation, and induce the