Protein chip technology in cancer detection.docVIP

Protein chip technology in cancer detection [Keywords:] protein chip; ovarian cancer; prostate cancer; tumor; clinical examination Protein chip technology in the fastest progress in the field of cancer research. With the occurrence of tumor cells, tumor proteins occur in some patients is upward or downward, or to generate new tumor associated with abnormal protein, while the protein chip technology to depict all the protein in patients with fluid expression. In accordance with normal and abnormal protein expression profile differences in order to establish tumor fingerprint, fingerprint advantage is not subject to any single tumor marker sensitivity and specificity of the restriction could be as early as possible to reflect the tumor occurrence and development of the situation. Early tumor diagnosis, prognosis and monitoring, efficacy assessment and prognosis are important. At present, the protein chip for tumor research has found, including ovarian cancer, prostate cancer, breast cancer, bladder cancer, lung cancer and other related proteins and tumor pathogenesis research areas have made considerable progress. A prostate cancer Prostate cancer is the most common male cancer, prostate-specific antigen (PSA) is to test the main markers of prostate cancer, but because of its low specificity, and therefore the early diagnosis of prostate cancer, the application has been limited. The use of protein chip mass spectrometry technology can rapidly from cell lysates, plasma, semen identified four kinds of detection of prostate cancer associated markers: prostate-specific antigen-specific acid phosphatase, specific membrane antigen, prostate-specific peptides. Combination of laser capture microdissection technology, from access to the net in prostate cancer cell lysates were discovered three proteins increases with protein chip technology can be detected by serum prostate specific antigen test for prostate cancer patients not [1]. 2 Ovarian Cancer Ovarian cancer