Progress in phototherapy of vitiligo.docVIP

 PAGE \* MERGEFORMAT 12 Progress in phototherapy of vitiligo [Abstract] Vitiligo is a depigmentation disorder. The light therapy treatment as one of the main widely used. In this paper, including PUVA, narrow band UVB, 308 nm excimer laser light therapy in recent years, the development of reviewed. [Keywords:] vitiligo, PUVA 308 nm narrow-band ultraviolet excimer laser As we all know, vitiligo depigmentation is a disease affecting patients with severe physical and mental health, especially in patients exposed parts generally have a heavy spiritual burden. But so far, because of its specific etiology is not fully understood, there are easy to diagnose difficult treatment characteristics, therefore, now use more combination therapy (including surgery, medication and physical therapy. The photochemical therapy as an important part of physical therapy, as we are concerned, this paper recent research progress of phototherapy of vitiligo are reviewed. 1 Photochemotherapy Photochemotherapy is the photosensitizer and UVA (320 480nm UV, skin absorption is small, most of the table Pida through leather, leather and even with treatment for the disease in Central. The possible mechanisms: promotion of melanocyte DNA replication, the mitotic cycle time, melanosome number of sudden increase in melanocytes, tyrosine, and increased expression of a functional increase in the number of melanocytes, mainly the following. 1.1 psoralen photochemotherapy (PUVA) 8-methoxypsoralen in 1948 that for the treatment of vitiligo, but the UV plus psoralen treatment of vitiligo was first proposed in 1974 by the Parrish, initially for the treatment of psoriasis, soon found that UVA can activate the activity of 8-methoxypsoralen has been in use today. is more approach is [1]: For the generalized topical treatment of vitiligo or ineffective treatment before the first meeting of oral 8-methoxy bone fat hormone (0.5 ~ 0.6mg/kg in two hours according to UVA. should first be deter