Protein chip applications in cancer research_0.docVIP

Protein chip applications in cancer research [Keywords:] ovarian carcinoma; related factors; Research Ovarian cancer is a common female genital malignancy of the three. Gynecologic cancer mortality rates of ovarian cancer first, has become a serious threat to women’s lives and health of the primary tumor. The lack of early diagnosis of ovarian cancer index, easy to early metastasis, invasion and its resistance to chemotherapeutic drugs is the cause of its high mortality rate, the key factors influencing the prognosis. invasion and metastasis is a complex pathophysiological process, not only between tumor cells, tumor cells and the interaction between host cells , but also many biologically active molecules involved in complex interactions between the regulatory mechanism. In this paper, the invasion and metastasis related factors were reviewed. Adhesion molecule-1 in ovarian cancer invasion and metastasis Cell adhesion molecules (cell adhesion molecules, CAMs) is produced by cells present in the cell surface, mediated cell-cell or between cells and matrix combination of mutual contacts and a class of molecules, mostly glycoproteins, a small number of glycolipids , distributed in the cell surface or extracellular matrix (extracellular matrix, ECM) in order to ligand - receptor play a role in the form corresponding to, leading to cell and between cells or between cells and stromal cells - Matrix - the adhesion between cells involved in cell signal transduction and activation, cell spreading and movement, cell growth and differentiation and a series of important physiological and pathological processes. so far found that the adhesion molecules, including immunoglobulin superfamily, integrin family, calcium-dependent adhesion Su family, selectin family, CD44 family, the family of vascular adhesion factors, including cadherin family, integrin family, CD44 family of immunoglobulin superfamily, selectin family have been associated with tumor metastasis [ 1].