Prothrombotic state markers F1 +2 TAT AT- D-Dimer of early predictive value of recurrent abortion.docVIP

Prothrombotic state markers F1 +2 TAT AT- D-Dimer of early predictive value of recurrent abortion Of: Zhu Liqiong Chen Hui Zhang Jianping Zhang Rui Wang Yunhui Dubi Jun Tan Jianping Liu Yinglin [Abstract] [Objective] To investigate the molecular markers of prothrombotic state: prothrombin fragment F1 +2 (F1 +2), thrombin - antithrombin complex (TAT), antithrombin (AT-), D-dimer (D-Dimer) and early recurrent spontaneous abortion (RSA) the relationship between the various molecular markers of prothrombotic state (PTS) due to the diagnostic value of RSA. [Method] RSA 103 patients who had been pregnant (AEP group), 103 patients had a history of RSA who are not pregnant (ANP group) and 40 cases of normal pregnancy were (NEP group) and 40 healthy nonpregnant persons (NNP group) in serum F1 +2, TAT, AT- , D-Dimer levels; and the ROC curve method to determine the time of PTS caused by the RSA over the best threshold of each indicator. [Results] 1. ANP plasma F1 +2, D-Dimer levels were significantly higher than the NNP group, the difference was statistically significant (P lt;0.008); and 3 times miscarriage than those who target high levels of 2, the difference was statistically significant (P lt;0.016 7). F1 +2 and D-Dimer in patients judged not pregnant RSA prothrombotic state exists the best screening cutoff values #8203;#8203;were 55.11 nmol / L (AUC = 0.767) and 233.50 g / L (AUC = 0.636) .2. ANP plasma TAT levels higher than the NNP group, AT- low levels of in the NNP group, but the difference was not statistically significant (Pgt; 0.008). AEP plasma F1 +2, TAT, D-Dimer levels higher than the NEP group, AT- level lower than the NEP group, but the difference was not statistically significance (Pgt; 0.008). [Conclusion] RSA is correlated with the PTS; RSA patients before pregnancy has been expressed as PTS, PTS marker F1 +2, D-Dimer RSA can be used to cause abortion without screening pregnant populations, the The higher the level, the greater the possibility o