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2017-05-05 发布于浙江
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Proto-oncogene GFI-1 in acute leukemia bone marrow cells of Study.doc

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Proto-oncogene GFI-1 in acute leukemia bone marrow cells of Study

Proto-oncogene GFI-1 in acute leukemia bone marrow cells of Study [Abstract] Objective: To study the proto-oncogene GFI-1 in acute leukemia bone marrow cells expression. Methods: The PCR method of detection of GFI-1 in acute leukemia patients the expression of bone marrow cells. Results: GFI-1 in acute leukemia bone marrow cells the expression of positive, normal negative. Conclusion: GFI-1 involved in the pathogenesis of acute leukemia. [Keywords:] Acute leukemia; GFI-1 gene; bone marrow cells GFI-1 (growth factor independence-1) in various types of blood cells were expressed, is a kind of blood cell proliferation and differentiation play an important role in the proto-oncogene. GFI-1 position in the human chromosome 1p22 [1]. Of its encoded protein GFI-1 is a 55 kDa of nucleoprotein and through its unique sequence structure (TAAATCAC (A / T) GCA) combined with DNA [2]. GFI-1 protein in its zinc-finger-terminal sequence containing six C2H2 structure of its N-terminal has 20 amino acids with a SNAG (Snail/Gfi-1) structure [3]. GFI-1 is through these structures combined with their target genes and suppress the expression of its target genes in order to play its biological effects [4-11]. ETO is a 821 fusion protein generated by chromosomal translocation of a part of, and acute myeloid leukemia, particularly in the pathogenesis of M2. McGhee, etc. found in GFI-1 and ETO and associated proteins in vitro and in vivo in contact [12]. This shows that GFI-1 and the incidence of acute myeloid leukemia is also a relationship, but the GFI-1 in the pathogenesis of leukemia in the role is not yet clear whether the expression of ETO? 1 Materials and methods 1.1 General information on newly diagnosed cases of 24 cases of acute leukemia in 13 males and 11 females, aged from 23 to 80 years, mean 49 years old. According to FAB classification M1 3 cases; M2 patients, 4 cases; M3 in 7 patients; M4 patients, 4 cases; M5 5 patients; ALL patients in 1 case. And collected five case