Progress in structure modification of antibiotics.docVIP

 PAGE \* MERGEFORMAT 13 Progress in structure modification of antibiotics 【Key Words】, antibiotics;,,,, structure modification Abstract: The appropriate modification of the structure of natural antibiotics can improve its performance, is to explore the development of new drugs is one effective way. In this paper, structural modification of antibiotics, the study status and progress, citing the extended antibacterial spectrum, enhance the antibacterial activity, overcome resistance, to improve the pharmacokinetic properties, reduced side effects, as well as low toxicity agent needs to adapt to modified examples of success. Not all antibiotics can be modified through the modification of Ru Yuan to get good things, but in today’s troubled new antibiotics screening of natural products obtained by appropriate structural modification is necessary. Keywords:: antibiotics; structure modification Advances in structural modification of antibiotics ABSTRACT Ingenious modification of structure of natural antibiotics could improve their properties, which is one of ways to search for new drugs. In this paper some successful examples of structural modifications in expansion of antibacterial spectrum, increase of antibacterial activities, relief of resistance, improvement of pharmacokinetic properties, alleviation of toxicity and requirement for preparation were summarized. Although wishful products could not be obtained from any antibiotic, which has been modified. In these days of difficulty to search for new antibiotics, the modification of structure of natural antibiotics is necessary. KEY WORDS Antibiotics; Structural modification An appropriate modification of the structure of natural antibiotics can improve its performance, is to explore the development of new drugs is one effective way. Listed in the calendar year, the new antibiotics, the structural modification of the proportion of goods increased year by year (Table 1), si