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PSK on experimental liver injury in antioxidant enzymes free radicals and nitric oxide content in.doc

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PSK on experimental liver injury in antioxidant enzymes free radicals and nitric oxide content in

PSK on experimental liver injury in antioxidant enzymes free radicals and nitric oxide content in Author: Sun-based cases, official Juan Lu Tao, Zhao Jie, Zhang Hongmei [Abstract] Objective To observe the PSK (CVP) on the CCl4 hepatic injury antioxidant enzymes, free radicals and NO concentration changes of CVP liver injury in rats. Method 4-month-old Kunming mice 50, sub-normal control group, pathological model group, CVP protect the components of high, medium and low three groups, normal diet, free drinking water. CVP group by day, 50,100,200 mg / kg body weight fed a sub-PSK, feeding 8 d, the Last gavage 2 h, the normal control group, intraperitoneal injection blending oil solution, the other groups intraperitoneal injection of 0.15? L4 blend oil solution (10 ml / kg body weight), 12 h after fasting could not help but water, 18 h after the mice were killed, the liver weighed out the calculation of liver somatic index; Preparation of 10% of the liver homogenate were measured SOD, GSH-Px, NOS activity and MDA, GSH, NO levels. Results Compared with model group, CVP can reduce the liver somatic index (P amp;lt;0.05) and MDA content (P amp;lt;0.001), increased antioxidant enzyme activity and GSH content (P amp;lt;0.01), reduced NOS activity and NO content ( P amp;lt;0.01). Conclusion CVP reduce liver damage caused by inflammatory reaction and improve antioxidant enzyme activity and GSH content, speed up the free radical scavenging, reducing the amount of NO, on experimental liver injury protection. [Keywords:] liver injury in carbon tetrachloride, nitric oxide free radicals Abstract: ObjectiveTo study the protective effect of Coriolus versciclor polysaccharides on CCl4-induced liver injury in rats through observing the contents of antioxidase, free radicals and NO. MethodsFifty Kunming mice of 4 months old were divided into control group, model group, groups treated with small, middle and large dose of CVP. Gastric perfusion was done with 50 mg / kg, 100 mg / kg