Progress of immune tolerance in kidney transplantation.docVIP

 PAGE \* MERGEFORMAT 17 Progress of immune tolerance in kidney transplantation [Keywords:] kidney transplantation, immune tolerance Organ transplantation is the treatment of end-organ failure and effective method, although many new application of immunosuppressive drugs the incidence of acute rejection has decreased significantly, but the incidence of chronic rejection and graft loss of organ function and not reduced, the United States 1993 to 2002 5-year graft body and 10-year survival rates were 65.7% and 36.4% [1]. immunological tolerance immune specificity, and immune deficiency or drug-induced inhibition of the immune system in general, compared has obvious advantages and can significantly reduce the amount of immunosuppressive drugs, reducing opportunistic infections, the incidence of poisoning, so the induction of graft specific tolerance in organ transplantation is to solve the ideal method of rejection, many scholars now Research in this area has been committed, is to be reviewed. Cloning incompetent mechanisms and methods for tolerance induction T cell response to antigen-free state or inactivation, but not associated with cell death known as the cloning of incompetence (clonal anergy). T cell activation to provide APC must accept full-time dual signal that the TCR MHC peptide complex on their own recognition provide the first signal. and by the APC and the T cell surface adhesion molecules provides a second signal that the costimulatory signal. In addition, activation of T cells to promote the third category of signals (T cell growth factor, TCGFs) on T cells play an immune response also plays an important role. common cellular immunity start the third signal is: IL 2, IL 4, IL 7, IL 9, IL 15, IL 21, among which IL 2 response in graft rejection plays a crucial role [2]. T cells are the role of costimulatory signals can induce IL 2 secretion after anti-apoptotic protein Bcl family and the expression and role of IL 2 to proliferate and diff