Progress in thyroid cancer proteomics research.docVIP

 PAGE \* MERGEFORMAT 17 Progress in thyroid cancer proteomics research [Keywords:] Thyroid cancer; tumor proteomics; two-dimensional gel electrophoresis; MS Abstract: Proteomics is the emergence in the post-genomic era, a new field of research, cancer proteomics is its major branches. In this paper, thyroid tumor-specific molecular markers, as well as thyroid cancer molecular target therapy such aspects as described in detail in recent years, status of thyroid cancer proteomics research. Keywords:: thyroid cancer; tumor proteomics; two-dimensional gel electrophoresis; MS Progress in research of thyroid oncoproteomics Shi Bingyin, Li hao (Department of Endocrinology, the First Affiliated Hospital, Medical School of Xian Jiaotong University, Xian 710061, China) ABSTRACT: Proteomics is a new research area of the postgenomic era. Oncoproteomics is an important branch of it. Here we discuss the investigative outcome of thyroid oncoproteomics in recent years, such as specific tumor biomarkers and antineoplastic drug. KEY WORDS: thyroid cancer; oncoproteomics; twodimensional electrophoresis; mass spectrometry Endocrine tumors of thyroid cancer is the most common form of the current from the genetic level it was extensively studied, but the ultimate function of genes through the corresponding proteins play a role, while in the DNA-mRNA-protein transcription and translation process existence of post-transcriptional shearing, post-translational modification and processing a variety of ways, so the expression of genes and proteins there are certain differences between, it is necessary from the overall level of the protein revealed the occurrence of cancer development, explains the nature of cancer. Cancer proteomics using proteomics techniques, such as two-dimensional gel electrophoresis (twodimensional electrophoresis, 2DE), electrospray ionization mass spectrometry (electrospray ionization mass spectrometry, ESIMS), matrix-assisted laser desorption ionization t