Psoralen extract PI13K-Art Experimental study of signal pathway.docVIP

下载本文档

2
0
约4.13千字
约 4页
2017-05-05 发布于浙江
举报
版权申诉

Psoralen extract PI13K-Art Experimental study of signal pathway.doc

1、本文档共4页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Psoralen extract PI13K-Art Experimental study of signal pathway

Psoralen extract PI13K/Art Experimental study of signal pathway [Keywords:] psoralen extract PI13K/Art signaling pathway Incidence of cancer is a multi-factor, multi-stage, multi-step, multi-gene changes in the results, including the activation of oncogenes and inactivation of tumor suppressor genes. With the growth of tumor cells, proliferation and apoptosis in-depth study of the molecular mechanism of signal transduction pathway as tumor targeting of treatment and resistance reversal highlights. In recent years, studies have shown that phosphatidylinositol -3 kinase (phosphatidylinositol-3-kinases, PI3K) signal transduction in the tumor plays an important regulatory role. Cells under the effect of a series of internal and external factors, by starting the PI3K/Akt signaling pathway and induce cell proliferation, differentiation and prevent cell apoptosis. In tumor cells to evade the process of anti-cancer drugs, PI3K/Akt signal transduction pathway may play an extremely important role, so PI3K/Akt signal transduction pathway is expected to become a new target for cancer therapy [1]. Previous studies in this research group showed that psoralen extract role of anti-tumor metastasis, but its mechanism has not yet entirely clear, in order to further explore its mechanism, we conducted a psoralen extract PI13K/Art signaling pathway Experimental study of the results now reported as follows. 1 Materials and methods 1.1 Preparation of drugs Psoralen plus 10 times the water soaking herbs 2h, decoction 2h, coolish filtering, dregs plus 8 times the water boiling 2h, coolish filtering, merging the two filtrate, concentrated to 1.0g (crude drug) / ml. 1.2 Preparation of animal model [2] 8 ~ 10d after transplantation to take the portability of pre-gastric squamous cell carcinoma (FC) organization, was prepared by 1 * 1010 / L of cell suspension of mouse cell suspension of the right axillary subcutaneous injection of 0.2ml / only. 1.3 Animal grouping and drug delivery