Pulsed drug delivery system and its application in the Application of Traditional Chinese Medicine.doc

 PAGE \* MERGEFORMAT 19 Pulsed drug delivery system and its application in the Application of Traditional Chinese Medicine Abstract This paper briefly introduces the characteristics of pulsed drug delivery systems, preparation techniques and pulsatile release dosage forms of existing, and in Chinese medicine research of the future were also discussed. Keywords: pulsed drug delivery system chrono-pharmacology of Chinese medicine formulations Delay Discussion of Pulsatile Drug Delivery System Applied to Chinese Medicine Preparation Keywords:: Pulsatile drug delivery system; Lag-time; chronopharmacology; Chinese medicine preparation Many physiological functions of the human body and physiological and biochemical indicators, such as blood pressure, gastric acid secretion, the secretion of certain hormones, etc., showing the changes in biological rhythms, a number of diseases such as hypertension, angina, asthma and other diseases there is an obvious onset of the day and night rhythm [1]. The best treatment of such diseases, the program is in accordance with the needs of physiological and treatment of timing, quantitative delivery. Pulsed drug delivery system is suited to this new drug delivery systems. Pulsed drug delivery formulations in accordance with the design principles of chrono-pharmacology, preparation, after a time lag, at the time of onset of the disease will quickly and completely release. The characteristics of a pulsed drug delivery systems Pulsed drug delivery system can choose the important moment of disease onset within the scheduled time automatically and quickly release the effective treatment dose of the drug, in order to ensure efficacy, reduce side effects, at the same time reduce the number of drug delivery, but also greatly increase patient compliance. Made of pulse oral formulations of drugs in general release in the small intestine or colon can avoid the liver first-pass effect, improve bio