Qin Lian Pills Optimization of Extraction Process.docVIP

 PAGE \* MERGEFORMAT 7 Qin Lian Pills Optimization of Extraction Process [Abstract] Objective Optimization qinlian pills best extraction process. Methods The orthogonal experimental design method to baicalin in order to evaluate targets, using high performance liquid chromatography extract baicalin content of the extraction process of the extraction method and solvent type of optimization. The best results in the extraction process by adding 12 times the amount of medicine in 60% ethanol soaked 60 min, reflux extraction two times, each time 60 min. Conclusion The Pill extraction method is simple, reasonable and feasible. [Keywords:] qinlian Pill orthogonal extraction of baicalin HPLC Qinlian prescription pills from ‘The 2005 edition of Chinese Pharmacopoeia Department of Qin contiguous Ⅰ . Prescription composition of baicalin 213 g, forsythia 213 g, berberine 85 g, Treats 340 g, red peony 213 g, licorice 85 g, with a heat detoxification, swelling pain of the effect. Attending organs Yun heat, headache, eyes be red, sore nose and mouth, hot dysentery abdominal pain, hot and humid vaginal discharge, sore throat boil embolism [1]. Pill is a solid dispersion of drug in the pills in the highly fragmented, with a large quantity of tablets taken, the collapse of Difference, drugs work slowly, compared with a large surface area, dissolution rate of rapid and high bioavailability. In this study, orthogonal experimental design, in order to Scutellaria the main active ingredient content of baicalin as the evaluation index, optimize the extraction process Qinlian pills, in order to develop a fast dissolution rate, bioavailability formulations provide the basis for a new high. An apparatus and materials Agilent 1100 HPLC, DAD detector, quaternary pump, Agilent 1100 workstation; Bp211D Electronic Analytical Balance (Germany, sartorius); RE-52AA rotary evaporator (Shanghai Yali-wing biochemical Instrument Factory); DZF-6050 vacuum drying box (on the Haibo Xun Industria