Qingdai soluble extract Preparation and solubility of solid dispersion systems research.docVIP

 PAGE \* MERGEFORMAT 25 Qingdai soluble extract Preparation and solubility of solid dispersion systems research 【Abstract】 Objective To investigate the total grinding technology for solubilization of insoluble drugs ability. Methods A total of grinding technology and the use of coprecipitation Qingdai soluble extract of solid dispersion, and to indirubin as an index, using HPLC determination of their apparent solubility. The results of grinding technology and co-precipitation method effectively improved the apparent solubility of indirubin, different studies have shown that carriers of research material in the hydrophilic hydroxyl carrier to improve the solubility of insoluble drugs have an important impact. Conclusions A total of grinding techniques can effectively improve the solubility of insoluble drugs. 【Key Words】 A total of ultrafine grinding technology insoluble drugs indirubin Abstract: ObjectiveTo investigate the solubility enhancement of solid dispersions prepared by cogrinding method. MethodsA coground mixture and solid dispersions of lipophilic extract from Indigo were prepared with water-soluble polymer. An HPLC method was established for the determination of indirubin to study the solubilities of the solid system with indirubin as a reference substance. ResultsThe results showed that the solubility of indirubin in solid dispersions prepared by cogrinding method were remarkably enhanced as well as coevaporation method.It was suggested that hydroxyl group in series of water-soluble polymers plays a key part in the solubility enhancement from the result of the effect of polymer species in the coground mixture on indirubin solubility. ConclusionThe present cogrinding method is very effective for improvement of solubility of poorly water-soluble drugs. Keywords:: Cogrinding method; Superfine smashing; Poorly water-soluble drug; Indirubin A total of Grinding Technology (Cogrinding method) is developed in recent ye