Qingfei Huatan Decoction of erythromycin on COPD rat model of the Lung Phlegm-Heat obstructing the efficacy and mechanism of.doc

 PAGE \* MERGEFORMAT 7 Qingfei Huatan Decoction of erythromycin on COPD rat model of the Lung Phlegm-Heat obstructing the efficacy and mechanism of Author: Huang Mei-Wen Chen decided he enjoyed apricot Gong Yao Yulan Zhang Hua-Ling [Abstract] Objective: To investigate the Qingfei Huatan Decoction of erythromycin on chronic obstructive pulmonary disease (COPD) in rat serum, lavage fluid (BALF) of interleukin -8 (IL-8) expression and airway inflammation in impact. Methods: 40 SPF Wistar rats were randomly divided into four groups, using multiple factors modeling COPD rat model was established by in order to observe the Qingfei Huatan Decoction of erythromycin on COPD serum, BALF of IL-8 expression and the impact of airway inflammation. Results: Compared with the blank group, model group, the rats appeared small airway tissue damage, the wall inflammatory cell infiltration, vascular proliferation and alveolar integration, serum and BALF of IL-8 were significantly increased; Compared with model group, the red mycin group after the intervention in the application of erythromycin in rat small airway tissue damage occurs, the wall inflammatory cell infiltration, vascular proliferation and fusion of alveolar improved, serum and BALF levels of IL-8 decreased significantly, with statistical significance; erythromycin erythromycin Qingfei Huatan Tang group than in the same test group index decreased significantly. Conclusion: Qingfei Phlegm Decoction erythromycin can reduce the blood and BALF of IL-8 expression significantly inhibited changes in airway inflammation, suggesting that Qingfei Huatan Tang in treating airway inflammation in COPD. [Keywords:] Qingfei Huatan Tang; COPD; IL-8; airway inflammation 〔 Abstract〕 Objective To discuss the effects of Qingfei Huatan decoction combined with erythromycinin COPD (chronic obstructive pulmonary disease) model rats, including IL-8 in serum, BALF and airway inflammation. Methods 40 SPF level Wistar rats were randomly divid