Qiongyugao HBxAg hepatocellular carcinoma cells inhibited expression and the role of prevention and treatment of primary liver cancer.docVIP

 PAGE \* MERGEFORMAT 6 Qiongyugao HBxAg hepatocellular carcinoma cells inhibited expression and the role of prevention and treatment of primary liver cancer Author: Xiao-Yin Chen WEI Chun Shan, TONG Guang Dong Mao Huijun, Fang Xia, Zhen-You Jiang [Keywords:] liver cancer;, Qiongyugao;, HBxAg Preventive and therapeutic effects of qiongyugao on hepatocellular carcinoma via inhibitionoftheexpressionofHBxAg in hepatic carcinoma cells [Abstract] AIM: To investigate the effects of qiongyugao on the expression of hepatitis B x antigen (HBxAg) in BALB / cnu mice into which human hepatic carcinoma cells were transplanted, and to analyze its specific mechanism in prophylaxis and treatment of hepatocellular carcinoma. METHODS: A nude mouse model with the transplantation of human hepatic carcinoma cells was established to observe the preventive and therapeutic effects of qiongyugao on the body weight and tumor weight of the mice. The expression of HBxAg in tumor and liver tissue wsa detected by immunohistochemical studies . RESULTS: Compared with model control group, prophylaxis and treatment with qiongyugao increased the body weight, depressed the tumor weight and inhibited HBxAg expression. The same efficacy was showed in both qiongyugao prophylaxis group and cyclophosphamide treatment group. CONCLUSION: Qiongyugao canslowdownthegrowthoftumorandinhibitthe expression of HBxAg , which may be an essential mechanism in prophylaxis and treatment of hepatocellular carcinoma. [Keywords] hepatocellular carcinoma; qiongyugao; HBxAg [Abstract] Objective: To observe the Chaqiong Jade ointment on human hepatocellular carcinoma cells in nude mice transplanted HBxAg expression, analysis of their expression by affecting the prevention and treatment of primary liver cancer HBxAg mechanism. Methods: To establish a model of human liver cancer cells transplanted in nude mice and observing Chaqiong jade cream prevention and treatment of mice body mass, quality of cancer, while using i