Qiweibaizhu Powder on human rotavirus infection in neonatal rat intestinal epithelial cells of the protective effect.doc

 PAGE \* MERGEFORMAT 11 Qiweibaizhu Powder on human rotavirus infection in neonatal rat intestinal epithelial cells of the protective effect Of: Jiang Xiao, Wu Rong reference, Tian Xuefei, HE double rattan, Li Jie, Li Shan, Cai Rui, Chen Ling-li, GAO Van [Abstract] Objective Qiweibaizhu Powder on human rotavirus (HRV) infection in neonatal rat intestinal epithelial cells in rats. Method 5 days old suckling mice orally infected with NIH to establish neonatal HRV diarrhea were randomly divided into 4 groups: normal group, model group, Qiweibaizhu Powder group, ribavirin group, neonatal rats in each group were treated with oral drugs to treat the corresponding drip, 3 times / d (normalized with the model group to saline.) 5, respectively, after treatment d killed suckling mice, taking neonatal rat small intestine stool test HRV, HE staining intestinal mucosa pathology. Results Qiweibaizhu Powder for 5 d neonatal rat intestinal feces HRV clearance was significantly better than the model group (P lt;0.05); Qiweibaizhu Powder group of intestinal mucosa in suckling mice significantly reduced lesions, and the model group, ribavirin group differences were statistically significant (P lt;0.05). Conclusion Qiweibaizhu Powder to remove the infection in the neonatal rat intestinal HRV, HRV infection significantly improved milk intestinal mucosal epithelial cell lesions. [Keywords:] Qiweibaizhu Powder; human rotavirus; intestinal epithelial cells; suckling mice Abstract: Objective To investigate the protective effect of Qiweibaizhu Powder against HRV infection of intestinal mucosal epithelial cells of suckling mice. Methods The 5-day-old NIH mice were made HRV diarrhea model by oral infection, and randomly divided into six groups: normal group (NG), model group (MG), Qiweibaizhu Powder group (BG), ribavirin group (ZG), suckling mice in each group were instilled corresponding drugs 3 times / d (NG and MG with normal saline) through the mouth. 5 d after treatment,