Quantum dots and its mechanism of cytotoxicity Progress.docVIP

 PAGE \* MERGEFORMAT 21 Quantum dots and its mechanism of cytotoxicity Progress [Abstract] quantum dots have excellent optical properties, in vivo and in real-time dynamic detection of a wide range of applications. The author briefly describes the basic properties of quantum dots and applications, focuses on the cytotoxicity of quantum dots in recent years and its influence factors such as research progress, and summarized the currently accepted quantum dot cytotoxicity mechanism. [Keywords:] quantum dots; cell toxicity; toxicology; Literature Review Quantum dots (quantum dot, QD) is a family or by the ~ ~ group elements consisting of nanocrystals is generally the semiconductor material for the core and covered the first two kinds of semiconductor materials to form, acceptable to stimulate the production fluorescence. The typical QD size 2 ~ 10 nm, with some traditional organic fluorescent dyes do not have the advantages: fluorescence intensity, good stability, good biocompatibility by modified later [1-2]; good lightfastness , fluorescence, long life, and strong anti-bleaching [3-5]; with the same excitation source excitation of different sizes QD, obtained from blue to red range of different colors of light [6-8], which can observe a static or dynamic a variety of subcellular structures in vivo multicolor fluorescence imaging makes it possible; emission spectra narrow and does not smear, can be reduced to the donor and acceptor emission spectra overlap, in order to avoid adjacent channel interference and to facilitate the observation [9-11 ]. The superior performance of QD to make a wide range of applications, such as research and development of new solar cells, light emitting devices, markers of genetic material, cell protein labeling and tracking, and the magnetic particles to visualize the tumor with magnetic hyperthermia, etc. [ 12-17]. With the extensive application of QD, the toxicity and bio-safety science and technology workers has als