Quetiapine and sulpiride in the treatment of negative symptoms of schizophrenia-control study on.docVIP

 PAGE \* MERGEFORMAT 5 Quetiapine and sulpiride in the treatment of negative symptoms of schizophrenia-control study on [Abstract] Objective To investigate the quetiapine in the treatment of schizophrenia negative symptoms of the clinical efficacy and safety. Methods were used quetiapine, sulpiride treatment of 40 patients with predominantly negative symptoms of schizophrenia patients with negative symptoms rating scale (SANS) and Clinical Global Impression Scale (CGI) assessment of efficacy; to side-effects scale (TESS) Assessment of side effects. Results After treatment, both groups SANS total score and CGI points were significantly lower than before treatment (P amp;lt;0.01); However, SANS total score after treatment between the two groups and the CGI was no significant difference in points (Pamp;gt; 0.05). TESS between the two groups after treatment total score compared to quetiapine group was significantly lower than that of sulpiride group (P amp;lt;0.01). Conclusion of quetiapine is a kind of negative symptoms of schizophrenia have better efficacy and less side-effects of antipsychotic drugs. [Keywords:] quetiapine; sulpiride; antipsychotic; schizophrenia / negative symptoms Quetiapine in 1998 by the FDA clearance to market and become first-line antipsychotic; in 2002 to enter the Chinese market, there are good prospects for development [1]. However, quetiapine in the treatment of negative symptoms of schizophrenia result little research, the authors of traditional antipsychotics sulpiride as a control, a prospective, double-blind controlled study ways to view Chakui sulfur level of the clinical effect of negative symptoms of schizophrenia and security. Reported as follows: An object and methods 1.1 object in line with CCMD-3 diagnostic criteria for schizophrenia; October 2004 ~ October 2005 hospitalized patients with schizophrenia. 2 weeks before treatment were not taking antipsychotics; exclusion of serious physical illness or nervous system disea