Quinquefolium 20soriginal PDS on experimental ventricular remodeling.docVIP

 PAGE \* MERGEFORMAT 13 Quinquefolium 20soriginal PDS on experimental ventricular remodeling Of: Lu Ying Dong Liu Ya Li Xiujiang trees were high-ranking officials Sui [Abstract] Objective of Panax quinquefolium 20s original PDS (PQDS late on acute myocardial infarction after reperfusion and the mechanism of ventricular remodeling. Methods rats ligating the left anterior descending coronary artery 2 h after Songzha prepared 28 d reperfusion of acute myocardial infarction with advanced left ventricular remodeling after reperfusion model, while applications PQDS treatment were determined after 28 d administration of rat heart ventricular remodeling morphological parameters, plasma angiotensin (AT ) and endothelin (ET levels. Results and ventricular remodeling model group, PQDS 50,100 mg kg-1 d-1 can significantly reduce the non-infarcted area of left ventricular septal thickness and cavity area / total area ratio of left ventricular (P lt;0.05 and P lt;0.01, reduced infarct collagen deposition (P lt;0.05, lower non-infarct zone and collagen protein ratio (P lt;0.05, and significantly decreased plasma AT and ET levels (P lt;0.05 and P lt;0.01. the two groups showed no significant difference. Conclusion PQDS can inhibit experimental myocardial infarction after reperfusion late ventricular remodeling, which may be associated with decreased levels of plasma ET AT and improve collagen remodeling associated . [Keywords:] 20s of the original PDS, myocardial infarction and late reperfusion, left ventricular remodeling Acute myocardial infarction, particularly in large areas of transmural myocardial infarction produces ventricular remodeling (1). Ventricular remodeling and cardiac rupture, aneurysm formation, cardiac enlargement, heart failure and arrhythmias, and other serious complications or even death ( 2). quinquefolium 20s original PDS (PQDS is Araliaceae Panax genus Panax quinquefolius (Panax quinquefolium L. total saponins purified from leaves. l