Radiation treatment of malignant bone metastases.doc

 PAGE \* MERGEFORMAT 3 Radiation treatment of malignant bone metastases [Abstract] malignant tumors of bone metastasis is one of the most common complication, which caused progressive bone pain, bone and joint dysfunction, spinal cord compression, pathologic fractures, serious impact on patient quality of life. Radiation therapy is an important bone metastasis of malignant tumor treatment. For the single bone metastasis can be the method of local radiotherapy, while the multiple bone metastasis can be localized radiotherapy, radionuclides, bisphosphonates such as combination therapy. [Keywords:] cancer; bone metastases; radiation therapy Bone cancer bone metastases can lead to structural damage, mainly for the purpose of bone pain, bone and joint dysfunction, spinal cord compression, pathologic fractures, serious impact on patient quality of life. Therefore, control over the use of radiation therapy of bone metastases and reduce the symptoms of pain relief has important clinical value. In this paper, the transfer of radiation treatment of malignant bone status and progress reviewed. A malignant bone metastasis principles of radiation therapy Malignant bone metastases include external beam radiation therapy, internal radiation and so on. The role of external irradiation for pain relief may be rays on the principle of bone tissue cytotoxicity and affect nerve endings to the polarization process, interfere with transmission of pain signals, inhibit bradykinin, prostaglandins and other pain in the secretion medium. Ray can also directly kill tumor cells, control tumor growth, so that lesions to narrow, reducing the pressure of periosteum and bone marrow cavity and ease the pain. At the same time Ray also allow an increase collagen synthesis, vascular fiber matrix production, increased activity of osteoblasts and new bone formation, is conducive to maintaining bone structure. Internal radiation is through intravenous injection, oral or inter-organization into